Cayman marked the arrival of the first American Airlines flight at Owen Roberts International Airport since the borders closed in 2020.
The flight, from Miami, touched down around 2pm on Thursday afternoon.
It comes after United Airlines returned to the jurisdiction on Saturday, marking the resumption of its routes from Newark, Washington (Dulles), Chicago and Houston.
Later on Thursday, Premier Wayne Panton announced that Cayman would be dropping the post-arrival lateral flow testing on days 2, 5 and 7 for securely verified travellers.
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